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Submit a link Submit text post Please activate this subreddit's custom style for access to extra functionality such as content filtersįor Sim mode, visit r/WarthunderSim! Rules ![]() ![]() Going Deeper: More about the 1 gene, 1 enzyme hypothesis and the importance within a metabolic pathway. This necessarily means that both P and Q have a functioning enzyme argininosuccinase (see Figure 1). The information in the table shows a (+) symbol in the last two columns indicating that both P and Q are able to convertĪrgininosuccinate to arginine (see Table 1). X (the other interpretation is that they have no enzyme but that is not consistent with the data in the table provided). Reinterpret the question: if neither P nor Q have a defective enzyme X, that suggests that both P and Q have a functioning enzyme So you can see that the figure provided indicates the 3 enzymes that are catalysts for the three reactions as shown. You should recognize that enzymes typically end with –ase and Neither mutant strain P nor Q have the defective enzyme: Question 2Īccording to the information provided, a conclusion that can be made with certainty is that Growth is indicated by (+), and no growth is indicated by (-). Table 1: Growth response of mutant strains in "minimal" media with supplements as Each gene in italics in theĭiagram produces one enzyme necessary for the synthesis of this essential amino acid required for growth. Other hand, if a "complete" medium is provided, containing all required amino acids, then Neurospora wouldįigure 1: A synthesis pathway for the amino acid arginine. The mutant would only grow if the enzyme product were to be added as a supplement. Mutating any one of the genes that makes an enzyme can produce a Neurospora strain that cannot Grows normally in nature (wild type) has enzymes that convert these simple substances into the amino acids necessaryįor growth. Medium which is a fluid containing only a few simple sugars, inorganic salts, and vitamin. The red bread mold Neurospora crassa grows well on a cultural plate with "minimal" MCAT Sample Question 2-3: Biology/Biochemistry High p53 concentrations: clearly we get the opposite of the above, meaning a decrease in CDK2. Which we already established means an eventual rise in CDK2. If PTEN goes up, then PIP3 must go down because of the negative feedback symbol), rise in AKT, rise in mdm2, decrease in p53 Thus we have a decrease in PTEN which will lead to a rise in PIP3 (if you are unsure, think of what happens Low p53 means low p21 which we establishedĪ mutation in the gene that produces PTEN: The great majority of mutations will result in an ineffective gene product Note that we used the mostĭirect route to get to CDK2 as the question used the words “most reasonably”. Mdm2 and low p53 (notice carefully, when we leave mdm2, there is only one place to go in the diagram becauseĪll the other symbols are pointing to mdm2 and only one symbol is pointing away). ![]() ![]() High cyclin G concentrations: From the bottom of Figure 1, we can see that high cyclin G leads to high Our instance, p21 is low (degraded) so this allows CDK2 to rise unchecked. In other words, when p21 is high, CDK2 goes low. Shows that p21 has a negative influence on CDK2. [Notice a key step inĭegradation of p21 implies that the concentration of p21 in its active form goes down. Which means there will be some downregulation (amount/concentration goes down). ![]() Allow us to follow each arrow that stimulates the next protein and each symbol for negative feedback ![]() ![]() ![]() The $ limit and tube as well as tube type futher limit your choices. Maybe something forgotten about that was never played by EC, Page, etc. So any suggestions on a Marshall (or similar) small Combo amp that I could find used, that is not that popular so that it is priced in my budget, but still kick ass would be ideal.Īny amps you guys can think of that fit the bill and are not heavily desired. So far I'm not finding a new one to fit the bill, so I think a used amp would be best.Ī lot of the used amps are very desirable and tend to cost as much or more then the new ones! So here's what I think that I really need and what I believe would give me the sound I'm looking for:Ī Low Watt Tube Amp running E元4 Power Tube that will give me the crunch of a JCM 800 50 watt Combo at low volumes that I can use to practice in the house under $300 ($350 max). I was originally thinking of the VOX AC4C1-12 with EL84 Power Tube, but not sure that I can get the sound I'm looking for out of that amp. But if not, I can always put it through the PA if needed. If it can also be used for small clubs/bars that would be great. The original purpose for this amp was mainly as a home practice amp so that I can crank it up without having the wife down my back complaining that its too loud. I think I'm getting off track here in what I really need. ![]() Just remember that db is a logarithmic scale so a change of less than 3db will be barely noticeable, a change of 6db will be very noticeable (typically being perceived as half as loud again) and a change of 10db will usually be perceived as being twice as loud. It's interesting to play around changing the wattage while leaving everything else the same and then compare that with the effect of leaving the wattage the same but changing the speaker efficiency. There is a great resource here where you can input the speaker efficiency and amp power along with a few other variables and it will calculate the sound pressure level. For info most guitar speakers will be in the 90 - 100db range. I was just using the Celestion blue as an example of an efficient speaker, there are many others at a much lower price, a lot of the Eminence speakers are high efficiency. I get a bit wound up when people start saying "you need x amount of watts to be loud enough" when there is far more to it than that (rant over!). Yes, sorry went a bit off topic and probably not being helpful to the OP. I think he should go with a Blues Junior used. ![]() Thank you for all of these explanations! You have made this idiot smarter which is not easy to do! all of my 20 amp have different speakers (I think) so your last postulate above is hard for me to prove without a ton of wrenching. What are the more efficient ones out there so an array may be tried? But I also know they are not a magic bullet in all amps. I now want to try some super efficient speakers. You out-scienced us with your VERY EXCELLENT TRUTH above. I guess as an upgrade to a $350 amp he buys. The next question is how do they SOUND in every amp. Wonderful! Send me all the specs for the currently available amps and how many db they will stomp out with what they have? Or preface any amp choice with a Celestion Blue ? Nobody DOES that! So a 5 watt amp with an efficient speaker can easily be as loud as a 50 watt amp with an inefficient speaker! As for the difference between a 12 watt amp and a 15 or 20 watt amp if they all had the same speaker I doubt if most people would hear any difference in volume level, there would be less than 3db difference between the 12 and 20 watt amps. There is very little noticeable difference in volume between the 5 watt amp and the 12 watt amp.Īs a guideline and assuming the same speaker configuration if you want an amp that sounds twice as loud as 5 watt amp you would need to go to a 50 watt amp, however if you have a 5 watt amp with a 90db speaker and change the speaker to a 100db it will then be twice as loud. I can only speak of my own personal experience on this but I have played many small venue gigs with a 5 watt amp fitted with a 100db Celestion Blue speaker and I regularly gig with a 12 watt tweed Deluxe style amp also fitted with a Celestion Blue and have never had a problem being loud enough, in fact I'm often being asked to turn down as I am too loud! This is playing with a blues / rock style band with a none too gentle drummer (is there any other sort of drummer! ?). ![]() ![]() ![]() ![]() Skiena,ĭiscrete Mathematics: Combinatorics and Graph Theory with Mathematica. ![]() "Permutations: Johnson's' Algorithm."įor Mathematicians. "Permutation Generation Methods." Comput. Knuth,Īrt of Computer Programming, Vol. 3: Sorting and Searching, 2nd ed. "Generation of Permutations byĪdjacent Transpositions." Math. The number of permutations of n objects taken r at a time is determined by the following formula: P ( n, r) n ( n r) n is read n factorial and means all numbers from 1 to n multiplied e.g. "Permutations by Interchanges." Computer J. One could say that a permutation is an ordered combination. "Arrangement Numbers." In Theīook of Numbers. The permutation which switches elements 1 and 2 and fixes 3 would be written as (2)(143) all describe the same permutation.Īnother notation that explicitly identifies the positions occupied by elements before and after application of a permutation on elements uses a matrix, where the first row is and the second row is the new arrangement. There is a great deal of freedom in picking the representation of a cyclicĭecomposition since (1) the cycles are disjoint and can therefore be specified inĪny order, and (2) any rotation of a given cycle specifies the same cycle (Skienaġ990, p. 20). This is denoted, corresponding to the disjoint permutation cycles (2)Īnd (143). The unordered subsets containing elements are known as the k-subsetsĪ representation of a permutation as a product of permutation cycles is unique (up to the ordering of the cycles). (Uspensky 1937, p. 18), where is a factorial. ![]() ![]() ![]() They are basically the hard hitters and supporters. The Therians(my favorite), who look human but have animal ears. There are the Celestrians, who are basically elves. A new Race feature adds in race skills, which are basically skills only certain race can learn.The races in the game are Earthlain, who are basically humans. The graphics are good for a 3ds game, but nothing groundbreaking. Yet its great to go from a forest to a canyon and then from a canyon to a graveyard created by a long forgotten war. The stratums are diverse but due to the fact it takes about 10 hours to reach the next one they can become a little boring towards the end. But lets be real, if you take away map making EO is no longer EO. The mapping system is as challenging as ever but with a full auto map some of the games frustration is alleviated. The true story isn't really revealed until about 40 hours and is fairly generic. ![]() The story is very thin( which ii what you should expect from an EO game so people can't complain). Imagine binding the legs, arms, and head of a boss for three turns and they can't retaliate as you beat the living daylights out of them. ![]() It can quickly give you the edge you need in a boss fight. Union skills are the latest addition to the series and is probably one of my favorites. The character customization is at its best, controlling the smallest details of your team is great. A large amount of grinding is often required to face each stratum boss, but that is just how Etrian games work. Its high difficulty curve makes this game hard to recommend to anyone but to hardcore RPG fanatics who don't mind getting killed by Acorns this is great fun. Its high difficulty curve makes this game hard to recommend to anyone but to hardcore One of the best EO games as well as one of the hardest. One of the best EO games as well as one of the hardest. only time will tell if this knocks of EO3 for my personal favorite EO game. if you like old school dungeon crawlers, EOV is a must play. Another key part of EO is the map creation and EOV is by far the best version of this, you have more pins to place and more options to make your own map of the dungeon, the combat is also very in depth with buffs and ailments playing a key role, choose your party well as the composition will play a key part in getting through each stratum. This is one aspect of EO that i really liked, it is really about your characters development as you attempt to conquer the sprawling dungeon. This is a core EO game, with a basic story to drive the character based role playing that centers on your guild and characters you choose to fill it with. This is a core EO game, with a basic Having played most of the EO games, with my favorite being EO3 I was instantly at home with this game. Having played most of the EO games, with my favorite being EO3 I was instantly at home with this game. With endless character customization, adventurers will cast and create their own party from four unique races and ten different classes to explore the uncharted labyrinth. Personalize your party to work to your advantage. Form your own party and partner up to unleash devastating attacks. Dangerous creatures and terrifying FOEs roam the labyrinth on every floor, so prepare to test your mettle with challenging turn-based battles. There's a reason why no one has ever reached the top. Some believe the ultimate techniques can be mastered there, and a number believe the lost treasures can be found at the top of the Yggdrasil Tree's boughs. Each culture has their own myth, some say great power will be granted, others believe the great mysteries will be solved. For it is said that whoever braves the dangers of the dreaded Yggdrasil Labyrinth and reaches the summit will have their greatest wish fulfilled. Each culture Etrian Odyssey V chronicles the quest of a new adventurer as he or she attempts to reach the crown of the towering Yggdrasil Tree. ![]() ![]() She claims that after winning the war, they imprisoned the Empress and her retainers in the Nisshoku's main temple, including Yamiko. She describes them as oppressors who conquered the land from the shadow aligned Nisshoku, led by the Shadow Empress. Shrines placed sparsely throughout the level will refill all of the player's equipped techniques.Īragami is summoned into existence one night by an astral projection of Yamiko, a girl who identifies herself as a captive of the Kaiho, an army of light adepts. "Techniques" are more powerful, but have only two uses, cannot harm bosses, and can only be equipped one at a time (though the player can switch among them at any time). "Abilities" either rely upon Aragami's Shadow Essence or have infinite uses. Scrolls can be spent to unlock various useful skills, such as the ability to become temporarily invisible or to make corpses vanish. The player can also die by falling into water.Īs the player explores the levels, they may find several hidden scrolls. Any successful hit by a guard will kill Aragami instantly, returning the player to the last checkpoint to try again. If they find a corpse or see the player clearly, they will blow a horn, temporarily making all the guards actively search for Aragami, and causing them to become more suspicious if the player evades detection. Observing evidence of the player's presence (such as the sound of their comrades dying or spotting the player in the distance) will make guards suspicious, causing them to draw their swords and investigate. ![]() A guard can be killed instantly by attacking him within a certain range, but the only enemy that must be killed to complete a chapter is the boss (if present). There are also archers that patrol elevated areas and can spot the player at a longer distance while aiming, and swordsmen circled by a torch that kills the player on contact. Basic sword-wielding guards are the most common enemy, and can throw light projectiles to kill the player. Later in the game, the player gains a raven that will show the player the location of objectives through walls, and a set of bells that can be rung to lure enemies elsewhere.Įach chapter is patrolled by many guards. ![]() Shadow Essence is replenished by standing in the shadows, and drained by standing near intense light sources such as lanterns. Aragami can teleport to any part of the map in a certain radius where a shadow is cast, but doing so expends "Shadow Essence", displayed as a meter on his cape. To complete a chapter, the player must go to certain areas to collect items or destroy obstacles and reach the level's exit. The player controls a shadow spirit, Aragami, attempting to reach the end of all thirteen open-world chapters in order. This opposing army is formed by mystical warriors with the power to control the light. The player can teleport between shadows and faces an enemy army that goes by the name of 'Kaiho'. The players take the role of Aragami, an assassin with supernatural abilities. The game was originally titled Twin Souls: The Path of Shadows. Aragami (荒神) is an action-adventure stealth video game developed and published by Lince Works for Linux, Microsoft Windows, OS X, PlayStation 4, Xbox One and Nintendo Switch. ![]() ![]() It should command the attention of Instagram users immediately, causing them to hit that “follow” button!Think about it if you were choosing travel brochures at a travel agency, you wouldn’t pick up one that looked sloppy and inconsistent with text that you could barely read, would you? No. Think of your Instagram grid layout like your website, a brochure, or your brand portfolio. Then watch as new followers flock to your new and improved Instagram profile in droves! Why You Need to Create an Epic Instagram Grid Layoutįirst of all, though, why does having an awesome Instagram grid layout matter? Well, when an Instagram user lands on your page, they’re going to assess your photo grid and decide whether or not they want to follow you. ![]() In this way, you can easily plan your Instagram posts in advance and create a killer Instagram feed.Keep reading to discover how to create a beautiful Instagram grid layout and take your Insta feed to the next level. But, ultimately, the one thing that separates those Instagram accounts with a few hundred followers from those with thousands of followers is a consistent, eye-catching Instagram grid layout.After all, if a brand’s Instagram feed looked like a hot mess, would you follow it? Probably not… but then how do you create a beautiful Instagram feed? One sure-fire way is to stick to a consistent Instagram grid layout.A structured Instagram grid layout helps you plan the overall look of your feed based on each square on the grid. ![]() How do you decide whether or not to follow an Instagram account? The deciding factor for most of us is assessing an Instagram account’s feed to see if it looks interesting, professional, and relevant to us.Sure, Instagram users can follow a profile because they’ve heard of the brand elsewhere. ![]() ![]() WizNote focuses more on notes from quick collection, management … WizNote is a Note software, which is specially designed for internet users and mobile internet users. Notability stands on a framework that automatically associates notes with audio recordings, and supports all … Notability is the first truly integrated note-taking app for iOS. Want to see more alternatives for Sonocent Audio Notetaker? Notable You can use “note” as your personal notebook, if you want to share with friends, publish a note or notebook to …Ī fork of the original Notational Velocity with some additional and interface modifications. Plain text notepad with markdown support and to-do list manager for Linux, Mac OS X and Windows, which works in tandem with ownCloud’s note-taking application. It includes a calendar navigation, customizable templates, export … RedNotebook is a graphical journal and journal that helps you keep track of your notes and thoughts. Set reminder alarms, add them to a website or document, organize them using folders /, sync … It helps you to spend less time searching for links and more time browsing them.Ĭolorful and powerful sticky notes app for Windows and phones. We are not planning to offer a migration of data from other note taking solutions such as Sonocent Audio Notetaker into Glean.A hierarchical note-taking application, with rich text and syntax highlighting, storing data in a single XML or sqlite file.Ī personal home page and bookmark manager. Glean is an all new cloud-based solution and as such stores information differently than Audio Notetaker. ![]() Can Sonocent Audio Notetaker projects be transferred to Glean? No, the Glean subscription cost covers everything. Are there further costs for setup, training, cloud storage etc? Glean is based on a monthly subscription you can pay monthly, or pay for 1 year in advance. No, we are no longer selling Sonocent Audio Notetaker licenses. Can I still buy new licenses for Sonocent Audio Notetaker? We encourage you to try Glean which has been designed to solve the same challenges as Sonocent Audio Notetaker, but is much more flexible and easy to use and is in active development. However, you will no longer see improvements and updates to the product. You can continue to use Sonocent Audio Notetaker (so long as your Licence allows), and the product will be maintained and supported until August 2026 with ongoing support until 2027. ![]() Licenses and migration I bought Sonocent Audio Notetaker online, what happens now? You can learn more about Glean here or look at the frequently asked questions here: Glean FAQs. It is cloud based and can be accessed from any device, and recordings are accessible between your devices. Glean is our more modern, flexible and intuitive software. What is the difference between Sonocent Audio Notetaker and Glean? If an update to the operating system causes Audio Notetaker to become unoperational, then we will work to resolve this within the software. Maintenance means that we will work to resolve critical bugs that affect the operation and usability of the software on supported operating systems. What does maintenance of the product involve? We are encouraging users to transition to our new software Glean over the next few years. ![]() We will continue to maintain Sonocent Audio Notetaker until August 2026 and will continue to offer support until August 2027 to allow a phased transition period, but there will be no ongoing development for Sonocent Audio Notetaker. The future of Sonocent Audio Notetaker What is the future of Sonocent Audio Notetaker? ![]() ![]() ![]() This also feels darker than a hormone-fuelled need to see a naked girl at all costs. The ‘victims’ of the TikTok Invisible Challenge hack want to see behind the filter and undress creators who haven’t consented to that (although their curiosity may be encouraged by the post). Videos promising “unfilter” software will be promoted to the same TikTok accounts – a fact relied upon by the cybercriminals behind the attack. Videos using the Invisible Body hashtag will be shown to an audience who’ve proven themselves to be receptive to risqué media, a group of users who will likely have read the comment-section tips on how to view the bodies behind the filter. TikTok’s algorithm prioritizes viral content, but even this is somewhat tailored to the user. TikTok abides with EU data governance plan with Irish data center The malware presents a huge threat, as proved by the number of users joining the server – but how far do we sympathize with its victims? After all, they join the server specifically with the intention of violating the consent of the Challenge participants to be seen naked. Because the malware authors keep relocating the server and software as fast as it is shut down, the threat remains active. The malware steals device passwords, Discord account credentials and has the potential to take card details and cryptocurrency wallets. ![]() ![]() Instead, the repository hosts malware containing a file that installs a malicious Python package called “WASP Stealer (Discord Token Grabber).” That means that when users receive a private message containing a link that points to a GitHub repository, its legitimacy is rarely questioned. Now-deleted accounts promoted an app that would remove the Invisible Body filter, available through a Discord server called “Space Unfilter.” Once the server is joined, viewers will see videos of nude women that have supposedly been obtained using the software. The comment sections of these videos are frequently full of users asking how to remove the filter – a question that attackers promptly answered. ![]() |
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